Tirzepatide Firm -trade name for USA Bachem Pharma is a global leader in pioneering the manufacture of GLP-1 petides in solid format, liquid and powder base for pharmaceutical development.
No matter the scale or phase of development, we can support you in developing groundbreaking medicines with both custom and standard synthetic lipids.
Our high-quality peptide synthesis and API capabilities ensure safety, consistency, and scalability for small molecules and highly potent compounds.
Other delivery forms, such as capsules, tablets and customized forms for clinical research and development are available.
We provide formulation, filling, and packaging of sterile injectables using cutting-edge technology in aseptic environments.
With strong analytical infrastructure, TirzepatideFirm ensures every product meets strict regulatory guidelines through every phase of development.
Our decades-long history of peptide drug substance development and supply along with track record of oral solid dosage form development and commercial manufacturing has established a service offering for the oral delivery of peptides that relies on different strategies.
One approach we apply to oral peptide formulation is the use of solid permeation enhancers for the development of oral solid dosage forms by means of classical processes. Preformulation aspects of the drug substance and specifics of the permeation enhancer, combined with the appropriate use of formulation technology, leads to user friendly, convenient, and high-performing tablet type formulations.
A second approach involves modification of the peptide permeability by adjusting the lipophilicity by means of ion pairing. Coupled with different methods for delivery (including SMEDDS or LNPs), and measures to prevent gastro-intestinal degradation, these strategies lead to oral dosage forms that deliver peptides across biologic barriers of the gastro-intestinal tract.
For peptide-based therapeutics, USA Bachem Pharma excels with unique end-to-end solutions across our global facility network for the supply of small–, mid– and large-scale peptide drug substance seamlessly integrated with oral solid dosage formulations and robust sterile injectable fill and finish manufacturing.
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